
单 位:制药工程系
职 称:副教授
学 历:博士
Email:yuxinc@hbut.edu.cn
教育经历:
2005.9-2009.6华中农业大学植物科学技术学院植物科学与技术专业学士
2009.9-2015.6武汉大学药学院生物化学与分子生物学专业硕博连读博士
工作经历:
2016.3-2017.8美国加州大学河滨分校分子,细胞和系统生物学系Lab Assistant
2017.9-2019.5美国加州大学河滨分校生物医学科学系Assistant Specialist
2019.7至今 湖北工业大学 讲师、副教授
荣誉奖励:
2021年10月 湖北工业大学院级优秀班导师
2024年5月 湖北工业大学考研优秀班导师奖(20级制药1班考研率73.33%,全校第一)
2024年10月 湖北工业大学校级优秀班导师
社会兼职:
《中草药》杂志青年编委;《中国现代中药》杂志青年编委;《武汉大学学报(理学版)》杂志青年通讯编委;中国中西医结合学会临床药理与毒理专业委员会青年委员;中华中医药学会中药毒理学与安全性研究分会青年委员;中华中医药学会中药制药工程分会青年委员;Cardiovascular Innovations and Applications、Current Microbiology杂志审稿人。
研究方向:
1.中药/民族药的化学组分及药理学研究;
2.天然产物的肠道吸收、转运及代谢研究。
研究课题:
1.基于尤斯灌流系统的诃子特征化学成分抗溃疡性结肠炎活性及机制研究(82104536),国家自然科学基金青年项目,2022-2024,主持,结题。
2.尤斯灌流系统评价维药莳萝主要抗真菌成分的结肠腺癌细胞毒性及肠道代谢研究(2020CFB197),湖北省自然科学基金青年项目,2020-2022,主持,结题。
3.尤斯灌流系统评价肠道微生物影响莳萝主要抗真菌成分的跨肠膜转运(BRZD2002),新疆生产建设兵团塔里木盆地生物资源保护利用重点实验室开放课题,2020-2022,主持,结题。
4. Study on the organic amine metabolitesfrom amino acids transport through a rat colon(XBTK-2020003),湖北工业大学细胞调控与分子药物“111”引智基地青年学者国际合作研究项目,2020-2022,主持,结题。
5.毛诃子主要成分诃子酸抗溃疡性结肠炎活性及结肠转运代谢研究(BSQD2020034),湖北工业大学博士启动基金,2021-2023,主持,结题。
6.莲房原花青素抑制膳食寡肽-AGEs与受体RAGE-V结构域结合的分子机制研究,国家自然科学基金面上项目,2024-2028,参与,在研。
研究成果(#共同第一作者;*通讯作者):
1. Chen-Huan Qiao#, Tian-Tian Liu#, Yao-Yao Li, Shi-Dan Wang andYu-Xin Chen*.Exploring the promising potential of alcohol extract from the aerial part of dill in ameliorating DSS-induced ulcerative colitis in mice.Journal of Ethnopharmacology, 2025, 340, 119237.
2. 董婉绒,崔雨,刘恬恬,朱卫东,周高*,陈玉欣*.诃子化学成分和药理活性的研究进展[J].中成药,2024, 46(4):1246-1255.
3. Wan-Rong Dong, Yao-Yao Li, Tian-Tian Liu, Gao Zhou,Yu-Xin Chen*. Ethyl acetate extract of Terminalia chebula alleviates DSS-induced ulcerative colitis in C57BL/6 mice.Frontiers in Pharmacology, 2023,14,1229772.
4. Yao-Yao Li, Yu Cui, Wan-Rong Dong, Tian-Tian Liu, Gao Zhou,Yu-Xin Chen*.Terminalia belliricafruit extract alleviates DSS-induced ulcerative colitis by regulating gut microbiota, inflammatory mediators, and cytokines.Molecules, 2023, 28(15), 5783.
5. Yu-Xin Chen, Qiang Cai*. Plant exosome-like nanovesicles and their role in the innovative delivery of RNA therapeutics.Biomedicines, 2023, 11(7), 1806.
6. 崔雨,董婉绒,刘恬恬,朱卫东,周高,陈玉欣*.毛诃子化学成分及药理活性的研究进展[J].中国现代中药,2023, 25(1): 216-227.
7. Tian-Tian Liu, Lin-Jing Gou, Hong Zeng, Gao Zhou, Wan-Rong Dong, Yu Cui, Qiang Cai*,Yu-Xin Chen*. Inhibitory effect and mechanism of dill seed essential oil on Neofusicoccum parvum in Chinese chestnut.Separations, 2022, 9(10), 296.
8. Yu-Xin Chen#, Wei Li#, Hong Zeng, Gao Zhou, Qiang Cai*. Transcriptome analysis reveals the mechanism of dill seed essential oil againstSclerotinia sclerotiorum.Natural Product Communications, 2022, 17(8): 1-11.
9. 刘恬恬,周高,勾林晶,赵异,曾红,戴河双,蔡强*,陈玉欣*.莳萝精油及提取物的化学成分和药理活性的研究进展[J].中草药,2022, 53(8): 2582-2596.
10. Yuxin Chen, Meredith M. Dinges, Andrew Green, Scott E. Cramer, Cynthia K. Larive, Christian Lytle*. Absorptive transport of amino acids by the rat colon.American Journal of Physiology-Gastrointestinal and Liver Physiology,2020, 318: G189-G202.
11. Yuxin Chen#, Gao Zhou#,Bingxin Ma, Jing Tong, Youwei Wang*. Active Constituent in the Ethyl Acetate Extract Fraction ofTerminalia BelliricaFruit Exhibits Antioxidation, Antifibrosis, and Pro-apoptosis Capabilities in Vitro.Oxidative Medicine and Cellular Longevity,2019,Article ID 5176090.
12. Yuxin Chen, Neema Adhami, Manuela Martins-Green*. Biological markers of harm can be detected in mice exposed for two months to low doses of third hand smoke under conditions that mimic human exposure.Food and Chemical Toxicology,2018,122: 95-103.
13. Yuxin Chen, Ziping Zhou, Qigui Mo, Gao Zhou, Youwei Wang*. Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phospho-Isoform Signaling in Rats.BioMed Research International,2018,Article ID 1682743.
14. Yuxin Chen, Qigui Mo, Baibo Xie, Bingxin Ma, Xinyu Zang, Gao Zhou, Linyou Cheng, James Hua Zhou*, Youwei Wang*. Hepatoprotective activity of Yigan mingmu oral liquid against isoniazid / rifampicin- induced liver injuries in rats.Chinese Medicine,2018,9: 165-178.
15. Neema Adhami#,Yuxin Chen#, Manuela Martins-Green*. Biomarkers of disease found in mice after exposure to third hand smoke equivalent to those found in homes of smokers.Clinical Science,2017, 131: 2409-2426.
16. Yuxin Chen, Jing Tong, Lanlan Ge, Bingxin Ma, Jingsheng He, Youwei Wang*. Ethyl acetate fraction ofTerminalia belliricafruit inhibits rat hepatic stellate cell proliferation and induces apoptosis.Industrial Crops and Products, 2015, 76:364-373.
17. Yuxin Chen#, Hong Zeng#, Jun Tian, Xiaoquan Ban, Bingxin Ma, YouweiWang*. Dill (Anethum graveolensL.) seed essential oil inducesCandida albicansapoptosis in a metacaspase-dependent manner.Fungal Biology, 2014, 118:394-401.
18. Yuxin Chen#, Hong Zeng#, Jun Tian, Xiaoquan Ban, Bingxin Ma, Youwei Wang*. Antifungal mechanism of essential oil fromAnethum graveolensseeds againstCandida albicans.Journal of Medical Microbiology,2013, 62: 1175-1183.