
职称:副教授
学历:博士
邮箱:chenxiaorong@hbut.edu.cn
研究方向:天然产物的生物合成与合成生物学
学习、工作经历:
2019年12月获华中农业大学微生物学博士学位;
2020.07—2022.08,中国科学院上海有机化学研究所博士后;
2022.10—2025.04, 中科中山药物创新研究院助理研究员、副研究员;
2025.05—至今,湖北工业大学,副教授
研究课题:
1.国家自然科学基金青年科学基金项目(82304354),含稀有氨基酸Enduracididine模块的非核糖体肽类天然产物的发现及生物活性研究,2024-2026,30万,在研,主持;
2.国家自然科学基金重点项目(31930002),两类微生物源、高活性DNA烷基化剂生物合成中自抗性新机制的解析,2020-2024,311万,结题,参与;
3.国家自然科学基金面上项目(31870089),异腈类铜载体SF2768合成、降解、运输及调控机制的研究,2019-2022,61万,结题,参与;
4.湖北省杰出青年基金项目(2018CFA069),构建多效性生物农药产生菌的关键技术研究,2018-2020,10万,结题,参与;
5.中央高校基本科研基金(2662018PY053),新型DNA损伤修复蛋白功能的研究,2018-2020,24万,结题,参与。
学术成果:
1.Xiaorong Chen#, Rui He#, Aiai Sun, Jinyue Pu, Hai-Xue Pan,* and Gong-Li Tang*. A Secreted BBE-Like Enzyme Acting as a Drug-Binding Efflux Carrier Confers Microbial Self-Resistance to Mitomycin C. Organic Letters, 2024 (26): 1233-1237.
2.Xiaorong Chen, Hai-Xue Pan,* and Gong-Li Tang*. Newly Discovered Mechanisms of Antibiotic Self-Resistance with Multiple Enzymes Acting at Different Locations and Stages. Antibiotics-Basel, 2023 (12):35.
3.Xiaorong Chen#, Noah P. Bradley#, Wei Lu#, Katherine L. Wahl, Mei Zhang, Hua Yuan, Xian-Feng Hou, Brandt F. Eichman* and Gong-Li Tang*. Base excision repair system targeting DNA adducts of trioxacarcin/LL-D49194 antibiotics for self-resistance. Nucleic Acids Research, 2022 (50): 2417-2430.
4.Xiaorong Chen, Yuedi Sun, Shan Wang, Kun Ying, Le Xiao, Kai Liu, Xiuli Zuo and Jing He*. Identification of a novel structure-specific endonuclease AziN that contributes to repair of azinomycin B-mediated DNA interstrand crosslinks. Nucleic Acids Research, 2020 (48): 709-718.
5. Kedong Ma#,Xiaorong Chen#, Xiang Guo#, Yanwei Wang, Huimin Wang, Shan Zhou, Jinlong Song, Delong Kong, Jie Zhu, Weiwei Dong, Mingxiong He, Guoquan Hu, Bingqiang Zhao, Zhiyong Ruan*. Bacillus vini sp. nov. isolated from alcohol fermentation pit mud. Archives Microbiology, 2016 (198):559–564.
6.X-R Chen, C-B Shao*, Y-W Wang, M-X He, K-D Ma, H-M Wang, D-L Kong, X Guo, Y-Q Zhou and Z-Y Ruan*. Paenibacillus vini sp. nov., isolated from alcohol fermentation pit mud in Sichuan Province, China. Antonie van Leeuwenhoek, 2015 (107): 1429-1436.