
电子邮件:chenban@hbut.edu.cn
职务/职称:硕士生导师/副教授
专业:制药工程
讲授课程:《生药学》《AutoCAD》《数据驱动人工智能药物设计实训》《科研论文配图设计与制作(美育)》
研究方向:(1)中药药效物质;(2)计算药物化学
教育及工作经历:
2022年7月至今,湖北工业大学,制药工程,专任教师
2017年9月-2022年6月,广州中医药大学,中药学,医学博士
2013年9月-2017年6月,湖北中医药大学,制药工程,工学学士
研究课题:
数据驱动的天然Keap1-Nrf2 PPI抑制剂智能筛选与验证(2025KF03),2025-2027年,主持。
国家自然科学基金青年项目(82304707),计算机辅助开发中药抑制软骨细胞铁死亡治疗骨关节炎的先导化合物,2023年-2026年,主持。
湖北省自然科学基金青年项目(2023AFB373),基于Keap1-Nrf2 PPI筛选中药抑制软骨细胞铁死亡治疗骨关节炎的药效物质,2023年-2025年,主持。
湖北工业大学博士科研启动基金(XJ2022004001),计算机辅助研究中药抑制Keap1-Nrf2 PPI介导的软骨细胞铁死亡并治疗骨关节炎的物质基础与作用机制,2022年-2025年,主持。
个人荣誉:
Wiley威立中国开放科学2022年度作者奖,威立中国(2023年)。
指导学生成果:
全国大学生生命科学竞赛三等奖(2026年,24级本科生)
优秀毕业生(2026年,23级硕士生)
研究生国家奖学金(2025年,23级硕士生)
优秀研究生(2025年,23、24级硕士生)
研究成果(第一作者或通讯作者):
Xia, H., Liu, S., Li, Y., Zhou, Y., Hu, Y., Yuan, L., Li, X., Tian, L., & Chen, B. (2027). Integrated prioritization of candidate quality markers for Smilacis Chinae Rhizoma under the five-principle framework through chemical profiling, effectiveness evaluation, and bionic sensing. Journal of Ethnopharmacology, 372, 122170.
Chen, B., Xia, H., Li, Y., Ji, J., Hu, Y., Song, H., Zhang, Y., & Li, X. (2026). A principle-guided multistep workflow for screening potential quality marker candidates of Sanqi Shangyao tablet based on UHPLC-Q-orbitrap MS, in silico screening, and in vitro validation. Biomedical Chromatography, 40(8), e70554.
Yang, J., Peng, J., Wu, F., Hu, D., Pei, Z., Mei, X., Jiang, Q., Chen, B., Li, H., & Deng, W. (2026). A hydrolysis-enhanced deglycosylation strategy for flavonoids using a metal ternary deep eutectic solvent: Application to quercetin extraction from Euphorbia Humifusa. Separation and Purification Technology, 138143.
Chen, B., Liu, S., Xia, H., Li, X., Cai, R., Zhang, Y., Hu, Y., & Su, J. (2025). Integrated strategy for screening direct Keap1-Nrf2 PPI inhibitors from traditional Chinese medicine: A case study of Achyranthis Bidentatae Radix. Journal of Computer-Aided Molecular Design, 39(1), 83.
Chen, B., Liu, S., Xia, H., Li, X., & Zhang, Y. (2025). Computer-aided drug design in research on Chinese materia medica: Methods, applications, advantages, and challenges. Pharmaceutics, 17(3), 315.
Chen, B., Liu, S., Li, X., Cai, R., Li, C., Hu, Y., Su, J., & Lei, T. (2024). Database‐aided ultrahigh‐performance liquid chromatography Q‐exactive‐orbitrap tandem mass spectrometry putatively identifies 16 unexpected compounds and three anticounterfeiting pharmacopoeia quality markers for Perillae Fructus. Rapid Communications in Mass Spectrometry, 38(13), e9762.
Chen, B., Liu, S., Li, X., Li, C., Cai, R., Zeng, J., Hu, Y., Su, J., & Chen, S. (2024). Reconstruction of quality marker system for Ginkgo Folium tablet using UHPLC‐Q‐orbitrap MS, quantum chemical calculation, network pharmacology, and molecular simulation. Phytochemical Analysis, 35(7), 1659~1673.
Chen, B., Ouyang, X., Cheng, C., Chen, D., Su, J., Hu, Y., & Li, X. (2023). Bioactive peptides derived from Radix Angelicae Sinensis inhibit ferroptosis in HT22 cells through direct Keap1–Nrf2 PPI inhibition. RSC Advances, 13(32), 22148~22157.
Su, J., Li, D., Hu, Y., You, X., Guo, X., Li, X., & Chen, B. (2023). A novel C6-sulfonated celastrol analog as a tyrosinase and melanin inhibitor: Design, synthesis, biological evaluation and molecular simulation. Journal of Molecular Structure, 1283, 135288.
Chen, B., Su, J., Hu, Y., Liu, S., Ouyang, X., Cai, R., & Li, X. (2022). Antioxidant mechanisms and products of four 4’,5,7-trihydroxyflavonoids with different structural types. RSC Medicinal Chemistry, 14(1), 173~182.
Chen, B., Li, X., Ouyang, X., Liu, J., Liu, Y., & Chen, D. (2021). Comparison of ferroptosis-inhibitory mechanisms between ferrostatin-1 and dietary stilbenes (piceatannol and astringin). Molecules, 26(4), 1092.
Chen, B., Li, X., Liu, J., Li, Y., Dai, W., Chen, Y., & Chen, D. (2021). Ferroptosis‐inhibitory effect and possible mechanisms of ellagitannin geraniin. ChemistryOpen, 10(8), 737~739.
Chen, B., Li, X., Liu, J., Qin, W., Liang, M., Liu, Q., & Chen, D. (2019). Antioxidant and cytoprotective effects of Pyrola decorata H. Andres and its five phenolic components. BMC Complementary Medicine and Therapies, 19(1), 275.