职 称：副教授
学 历：博士
E-mail:guoguo0302@126.com
研究方向：纳米医药；智能纳米药物递送系统的设计及应用；磁性纳米材料在蛋白质、循环肿瘤细胞中的分离和应用；
学习、工作经历：
2011/07–至今，湖北工业大学，生命科学与健康工程学院，副教授
2008/09–2011/06，武汉理工大学，材料科学与工程学院材料学方向，博士
2006/06–2008/07，蚌埠学院，应用化学系，助教
2003/09–2006/06，武汉理工大学，应用化学系，硕士
1999/09–2003/06，武汉工程大学，制药工程系，学士
荣获奖励：湖北省科技进步三等奖
学生竞赛获奖：
全国大学生制药工程设计大赛一、二、三等奖
研究课题：
1.横向课题，纳米靶向药物研发平台建设，10万元，主持
2.国家自然科学基金，特异性富集和高选择性分离纯化目标蛋白质的复合磁性纳米粒子构建及分析（No. 21401051），25万元，主持
3.湖北省自然科学基金，特异性富集和高选择性分离纯化目标蛋白质的复合磁性纳米粒子构建（No.2014CFB595），3万元，主持
4.湖北工业大学自主创新项目，靶向多模式协同癌症诊疗纳米递送系统研究，主持
5.湖北省大学生创新创业训练，级联反应纳米炸弹用于抗肿瘤协同治疗，指导老师
研究成果：
1. Haowu Huang, Wenqiu Li, Yiwang Zhao, Shunyu Yao, Xiaoqing Liu, Mingxing Liu, andHuiling Guo*. Amplification of Oxygen-Independent Free Radicals Based on a Glutathione Depletion and Biosynthesis Inhibition Strategy for Photothermal and Thermodynamic Therapy of Hypoxic Tumors.ACS Appl. Mater. Interfaces2024, 16, 16, 20079–20091. (IF 8.8)
2. Yiwang Zhao, Shunyu Yao, Jing Huang, Xiaoyu Liang, Hongchao Deng, Ziyi Tong, Mingxing Liu, andHuiling Guo*. Integration of Fe (III)-Chelated Polydopamine and Diallyl Trisulfide for Boosting Ferroptosis to Reverse Multidrug Resistance and Inducing Synergistic Tumor Nanotherapy.ACS Appl. Nano Mater.2024, 7, 22, 25580–25592. (IF 5.5)
3. Wenqiu Li, Haowu Huang, Shunyu Yao, Yiwang Zhao, Mingxing Liu, Xiaoqing Liu,Huiling Guo*. Engineering of a double targeting nanoplatform to elevate ROS generation and DSF anticancer activity.Journal of Materials Chemistry B, 2024, 29: 7143-7152. (IF 6.1)
4. Siyuan Hao, Jingjie Zuo, Haowu Huang, Wenqiu Li,Huiling Guo*, Mingxing Liu, Hongda Zhu and Hongmei Sun. Tumor microenvironment (TME)-modulating nanoreactor for multiply enhanced chemodynamic therapy synergized with chemotherapy, starvation, and photothermal therapy,Journal of Materials Chemistry B, 2023, 11, 1739-1748. (IF 8.2)
2. Yi Zhang, Siyuan Hao, Jingjie Zuo,Huiling Guo*, Mingxing Liu, Hongda Zhu, and Hongmei Sun. NIR-Activated Thermosensitive Liposome-Gold Nanorod Hybrids for Enhanced Drug Delivery and Stimulus Sensitivity.ACS Biomaterials Science & Engineering 2023, 9 (1), 340-351. (IF 5.5)
3. Yi Zhang, Wenjing Wang,Huiling Guo*, Mingxing Liu, Hongda Zhu, Hongmei Sun. Hyaluronic acid-functionalized redox responsive immunomagnetic nanocarrier for circulating tumor cell capture and release,Nanotechnology, 2021,32(47):475102-475114.（IF 2.9）
4. Yi Zhang, Fengzhen Zhou, Wenjing Wang,Huiling Guo*, Mingxing Liu, Hongda Zhu, Hongmei Sun.Recyclable adsorbents based on Fe3O4nanoparticles on lanthanum-modified montmorillonite for the efficient phosphate removal,IET Nanobiotechnology, 2020,14(6):527-536.（IF 3.8）
5. Wenjing Wang, Fengzhen Zhou, Xiyao Chen, Zhengding Su,Huiling Guo*. High-efficiency Ni2+-NTA/PAA magnetic beads with specific separation on his-tagged protein,IET Nanobiotechnology, 2020, 14(1): 67-72.（IF 3.8）
6. Fengzhen Zhou, Wenjing Wang,Huiling Guo*, Honghao Sun. Silver triethanolamine loaded PVB/CO films for a pontential liquid bandage application,Journal of Biomaterials Applications, 2019, 33(10): 1434-1443.（IF 2.3）
7.Huling Guo*, Wenjing Wang, Fengzhen Zhou. Fast and highly selective separation of his-tagged proteins by Ni2+carrying monodisperse magnetic core-shell nanoparticles,Applied Physics A, 2019, 125: 333-334.（IF 2.5）
8.Huiling Guo*, Honghao Sun, Zhengding Su, Shuchao Hu, Xiaotao Wang. Fe3O4@PAM@NTA-Ni2+magnetic composite nanoparticles for highly specific separation of his-tagged proteins,Journal of Wuhan University of Technology-Materials Science Edition,2018, 33 (3): 559-565.（IF 1.3）
9.Huiling Guo*, Mengyun Li, Shu Tu, Honghao Sun. Selective binding and magnetic separation of His-tagged proteins using Fe3O4/PAM/NTA-Ni2+magnetic nanoparticles,IOP Conference Series: Materials Science and Engineering, 2018, 322:022017-.（EI）
10.李文秋,李瑞涛,杨宗山,肖文惠,郭惠玲*.一种新型复合抗菌剂的制备及其抗菌性能研究,应用化工, 2021, 50（1）150-153.（通讯作者，北大中文核心）
11.周凤珍,王文静,詹一丰,郭惠玲*.羧基功能化的荧光聚苯乙烯微球的制备及表征,化工新型材料, 2020, 48(3):105-108.（通讯作者，北大中文核心）
12.周凤珍,李文秋,王文静,郭惠玲*.载镧钙基蒙脱土吸附剂的制备及其吸附性能研究，化工新型材料，2020, 48(7):284-289.（通讯作者，北大中文核心）
13.周凤珍,李文秋,王文静,郭惠玲*.钙蒙脱土吸附镧的影响因素及其应用,应用化学, 2019,36(12):1413-1421.（通讯作者，北大中文核心）
14.王文静,孙宏浩,郭惠玲*.用于分离纯化组氨酸标签蛋白质的磁性复合纳米材料的制备,应用化工, 2019, 48(2): 244-247.（通讯作者，北大中文核心）
15.郭惠玲，一种复合磁性纳米粒子Fe3O4/MPS/PAA/NTA-Ni2+及其制备方法和其在分离纯化组氨酸标签蛋白质中的应用,专利号：ZL201610163717.7，授权日：2016.03.22.
