职 称：副教授
学 历：博士
E-mail:xdslfbm@163.com
研究方向：合成生物学；酶工程；
工作经历：
2012-至今 湖北工业大学 生命科学与健康工程学院
1. 荣获奖励
1. 湖北省科学技术进步奖一等奖，2016，保健酒现代制造关键技术及产业化.
2. 中国民营科技促进会民营科技发展贡献奖一等奖，2025，新型伊维菌素制剂的研制及推广应用。
3. 中国技术市场协会金桥奖一等奖，2024，动物体内外寄生虫病绿色防控技术集成与应用.
4. 中国发明协会发明创业奖创新奖二等奖，2021，高效伊维菌素预混剂的创制.
2. 主次课题：
[1] 发酵工程教育部重点实验室，重点实验室开放课题，1200583，霉菌毒素高效降解酶的设计与构建，2025-2027，在研。
[2] 发酵工程教育部重点实验室，重点实验室开放课题，03777，高底盘菌表达高效动保酶与中药饲料添加剂的智能化生产，2023-2026，在研。
[3] 发酵工程教育部重点实验室，重点实验室开放课题，02205，新型饲料添加剂生产的关键技术研究，2022-2023，结题。
[4] 省部共建工业协同发酵中心，开发基金，00017，高底盘菌株生物合成水飞蓟素，2022-2024，结题。
[5] 发酵工程教育部重点实验室，重点实验室开放课题，01794，天然药用植物生产新型高端绿色饲料添加剂和动保品，2021-2023，结题。
[6] 发酵工程教育部重点实验室，重点实验室开放课题，01718，多尺度代谢调控高低盘酵母工程菌株固态高密度发酵生产工业酵母粉，2021-2024，结题。
[7] 发酵工程教育部重点实验室，重点实验室开放课题，1200504，微生态制剂增效纤维素酶的多尺度代谢调控技术，2018-2019，结题。
[8] 发酵工程教育部重点实验室，重点实验室开放课题，1201002，多结构域纤维素酶的分子建构与催化机理研究，2017-2018，结题。
[9] 湖北中农华威生物工程有限公司，12018035，豆粕高效发酵技术，2017-2018，结题。
[10] 湖北省教育厅, 指导性项目，B2017024， 纤维素内切酶耐受乙醇分子改造与耐受分子机制研究,，2017-2018，结题。
[11] 湖北工业大学，湖北工业大学博士启动基金，BS2013022,酒糟生产饲料的纤维素酶基因工程菌株构建， 2013-2016 ，结题。
[12] 发酵工程教育部重点实验室，重点实验室开放课题，KFJJ201002, 海洋黑曲霉降解水葫芦产耐盐纤维素酶的研究，2010-2013，结题。
研究成果：
1. 唯一第一作者或唯一通讯作者发表SCI论文
(1) Jueyan Chen, Zhiyong Chen, Dejun Duan, Dongsheng Xue*. Advances in aflatoxins: toxicity mechanisms, detection technologies & control strategies. Microchemical Journal, 2026, 221.
(2) Dongsheng Xue, Jueyan Chen, Dejun Duan, Zhiyong Chen, Xihuo You*. Combinatorial engineering strategies to reconstruct Aspergillus niger for improving its cellulase production efficiency. World Journal of Microbiology & Biotechnology, 2025, 42(1).
(3) Dongsheng Xue, Jie Huang, Jueyan Chen, Qinyi He, Xuhao Zeng, Xiaowei Chen, Zhiyong Chen, Dejun Duan, Xihuo You*. Production of ethyl butyrate by a triple cascade process of the continuous submerged and solid state fermentation with corn stover. 3 Biotech, 2025, 15(7)
(4) Xingyue Xing, Xiaowei Chen, Xihuo You, Jie Huang, Dongsheng Xue*. Zearalenone degrading enzyme evolution to increase the hydrolysis efficiency under acidic conditions by the rational design. Food Chemistry, 2024, 456.
(5) Dongsheng Xue, Xingyue Xing, Benrong Jiang, Tianxiang Xiao, Xihuo You, Jie Huang, Feifan He, Chunjie Gong*. Ethyl lactate biosynthesis by the cascade of the aerobic process and the anaerobic process with corn stover. Cellulose, 2024, 31(3): 1497-1508.
(6) Tianxiang Xiao, Zhouquan Li, Xingyue Xing, Feifan He, Jie Huang, Dongsheng Xue*. Improving the activity and thermal stability of trypsin by the rational design. Process Biochemistry, 2023, 130: 227-235.
(7) Dongsheng Xue, Donghai Yao, Xihuo You, Chunjie Gong*. Tandem integration of aerobic fungal cellulase production, lignocellulose substrate saccharification and anaerobic ethanol fermentation by a modified gas lift bioreactor. Bioresource Technology, 2020,122902
(8) Dongsheng Xue, Yanming Jiang et al. Exogenous xylanase expression simultaneously with the indigenous cellulase to increase the cellulose hydrolysis efficiency.International Biodeterioration & Biodegradation, 2019, 140: 126-132.
(9) Dongsheng Xue , Donghai Yao, Xihuo You, et al. Green Synthesis of the Flavor Esters with a Marine Candida parapsilosis Esterase Expressed in Saccharomyces cerevisiae.Indian Journal of Microbiology, 2020, 60(2): 175–181.
(10) Dongsheng Xue, Huiying Chen, Yiran Ren, Shanjing Yao*. Enhancing of the activity and thermostability of the thermostable β-glucosidase from a marine Aspergillus niger at high salinity, Process Biochemistry, 2012, 47(4) :606-611.
(11) Dong sheng Xue, Long yuan Liang, Gang Zheng, Dong-qiang Lin, Qi-lei Zhang, Shan-Jing Yao*. Expression of Piromyces rhizinflata cellulase in marine Aspergillus niger to enhance halostable cellulase activity by adjusting enzyme- composition. Biochemical Engineering Journal 117, 2016, 156–161.
(12) Dongsheng Xue, Huiying Chen, Dongqiang Lin, Yixin Guan, Shanjing Yao*. A natural medium for cellulase by a marine Aspergillus niger using response surface methodology, Applied Biochemistry and Biotechnology, 2012, 167(7): 1963-1972.
(13) Dongsheng Xue, Jiangbo Wang, Shanjing Yao*. High production of halostable β-glucosidase from a marine Aspergillus nige irmmobilized on towel gourd vegetable sponges. Chinese Chemical Letters, 2015, 25(4):192-196.
(14) Dongsheng Xue, Dongqiang Lin, Chunjie Gong, Chunlong Peng, Shanjing Yao . Expression of a bifunctional cellulase with exoglucanase and endoglucanase activities to enhance the hydrolysis ability of cellulase from a marine Aspergillus niger. Process Biochemistry, 2016, 52: 115–122.
(15) Dong sheng Xue, Yuan-long Liang, Dong-qiang Lin, Chun-jie Gong, Shan-Jing Yao. Halostable catalytic properties of exoglucanase from a marine Aspergillus niger and secondary structure change caused by high salinities. Process Biochemistry, 2017, 58：85-91.
(16) Longyuan Liang, Dongsheng Xue*. Kinetics of cellulose hydrolysis by halostable cellulase from a marine Aspergillus niger at different salinities. Process Biochemistry，2017, 63：163-168.
(17) Dong-sheng Xue, Long-yuan Liang, Dong-qiang Lin, Shan-Jing Yao*. Thermal inactivation kinetics and secondary structure change of a low molecular weight halostable exoglucanase from a marine Aspergillus niger at high salinities. Appl Biochem Biotechnol, 2017,183(3)：1111-1125.
(18) Dongsheng Xue, Xuhao Zeng, Dongqiang Lin, Shanjing Yao*.Thermostable ethanol tolerant xylanase from a cold-adapted marine species Acinetobacter johnsonii, Chinese Journal of Chemical Engineering, 2018,02007.
(19) Dongsheng Xue, Xuhao Zeng, Dongqiang Lin, Shanjing Yao*. Ethanol tolerant endoglucanase from Aspergillus niger isolated from wine fermentation cellar. Biocatalysis and Agricultural Biotechnology ,2018,15:19–24.
(20) Xuhao Zeng, Dongsheng Xue*. Increasing of activity and thermostability of cold active butanol-tolerant endoglucanase from a marine Rhodococcus sp. under high concentrations of butanol condition. 3 Biotech, 2018,8:265-269.
(21) Dongsheng Xue, Dongqiang Lin, Chunjie Gong, Chunlong Peng, Shanjing Yao . Expression of a bifunctional cellulase with exoglucanase and endoglucanase activities to enhance the hydrolysis ability of cellulase from a marine Aspergillus niger. Process Biochemistry, 2016, 52: 115–122.
(22) Dong sheng Xue, Yuan-long Liang, Dong-qiang Lin, Chun-jie Gong, Shan-Jing Yao. Halostable catalytic properties of exoglucanase from a marine Aspergillus niger and secondary structure change caused by high salinities. Process Biochemistry, 2017, 58：85-91.
(23) Dong-sheng Xue, Long-yuan Liang, Dong-qiang Lin, Shan-Jing Yao*. Thermal inactivation kinetics and secondary structure change of a low molecular weight halostable exoglucanase from a marine Aspergillus niger at high salinities. Appl Biochem Biotechnol, 2017,183(3)：1111-1125.
(24) Dongsheng Xue, Jiangbo Wang, Shanjing Yao*. High production of halostable β-glucosidase from a marine Aspergillus nige irmmobilized on towel gourd vegetable sponges. Chinese Chemical Letters, 2015, 25(4):192-196.
(25) Dongsheng Xue, Huiying Chen, Yiran Ren, Shanjing Yao*. Enhancing of the activity and thermostability of the thermostable β-glucosidase from a marine Aspergillus niger at high salinity, Process Biochemistry, 2012, 47(4) :606-611.
(26) Dongsheng Xue, Huiying Chen, Dongqiang Lin, Yixin Guan, Shanjing Yao*. Optimization of a natural medium for cellulase by a marine Aspergillus niger using response surface methodology, Applied Biochemistry and Biotechnology, 2012, 167(7): 1963-1972.
2.专著
薛栋升，酿酒酶与酶制剂，化学工业出版社，北京，2017，35万字。
3.编撰教材
副主编，《遗传学》，十二五生命科学规划教材，2015。
参编，《生物工程设备》，中国高等教育出版社，2017。
4.授权发明专利
[1] 薛栋升. 一种双基因干扰提高黑曲霉纤维素酶酶活的方法, 2019-11-08, 中国, 201710045642.7.
[2] 薛栋升. 一种大片段基因整合提高黑曲霉纤维素酶酶活的方法，2019-09-10, 中国, 201710250564.4.
[3] 薛栋升. 温度、酸度控制纤维素酶在巨大芽孢杆菌中表达的方法，2019-11-08, 中国, 201610853941.9
[4] 薛栋升. 在缩减基因组的枯草芽孢杆菌中表达黑曲霉葡糖苷酶的方法, 2019-11-08,中国, 201610859539.1
[5] 薛栋升, 梁龙元. 增强芽孢杆菌在酸性环境中表达纤维素外切酶效率的方法, 2019-06-25,中国, 201610829645.5
[6] 薛栋升，梁龙元. 一种提高黑曲霉纤维素外切酶在高盐溶液中热稳定性和嗜盐度的方法, 2019-08-20, 中国, 201610559608.7
[7] 薛栋升,, 梁龙元. 利用纤维素内切酶和β-葡糖苷酶构建食品安全级载体及筛选培养基, 2019-10-25, 中国，201610597141.5
[8] 薛栋升,梁龙元. 温度、酸度控制纤维素酶在巨大芽孢杆菌中表达的方法，2019-11-08，中国，201610853941.9
[9] 薛栋升,梁龙元. 一种改变黑曲霉基因组局部结构提高纤维素酶表达量的方法, 2019-11-08, 中国, 201710045636.1.
[10] 薛栋升,梁龙元. 一种磷酸盐诱导启动子降低黑曲霉β-葡萄糖苷酶表达的方法，2019-11-10，中国，201611159365.4.
