学历：博士
E-mail：20260048@hbut.edu.cn
研究方向：胰腺癌发生与演化病理生理机制；细胞（器）自噬及膜蛋白胞内转运；多肽药物研发与肿瘤耐药。
学习工作经历：
2022年9月至2026年6月：湖北工业大学，轻工技术与工程，工学博士学位
研究课题：
1. 线粒体质量控制在胰腺癌演化中的作用机制及靶向策略研究（U25A20650）参与
2. 细胞调控与胰腺癌靶向药物研究（2024DJA037）参与
3. STYK1通过Wnt/β-catenin信号通路调控胰腺癌吉西他滨耐药的分子机制研究（32270768）参与
4. PKD2乙酰化调控自身功能的分子机制及其在遗传性多囊肾发展中的作用研究（32000797）参与
研究成果：
1. Zhou C#, Dong X#, Li S#, Xi Y, Liu Y, Qian X, Song Z, Zhou L, Zhang R, Lyu H, Xiao S, Guo D, Zhang Q, Liu W, Xiong Y, Wang Z, Yan C, Zhang Z, Zhu H, Chen XZ, Song Z, Tang J. Serine/threonine/tyrosine kinase 1 drives pancreatic carcinogenesis via GSK3β sequestration-mediated Wnt/β-catenin pathway hyperactivation. Signal Transduct Target Ther. 2025 Jun 30;10(1):205. doi: 10.1038/s41392-025-02292-x.
2. Huang Y#, Li S#, Liu Q, Wang Z, Li S, Liu L, Zhao W, Wang K, Zhang R, Wang L, Wang M, William Ali D, Michalak M, Chen XZ, Zhou C, Tang J. The LCK-14-3-3ζ-TRPM8 axis regulates TRPM8 function/assembly and promotes pancreatic cancer malignancy. Cell Death Dis. 2022 Jun 4;13(6):524. doi: 10.1038/s41419-022-04977-5.
3. Li S#, Xi Y, Dong XY, Yuan WB, Tang JF*, Zhou CF*. Evaluating the scope of human leukocyte antigen polymorphisms influencing hepatitis B virus-related liver cancer and cirrhosis through multi-clustering analysis. World J Gastroenterol. 2025 Feb 21;31(7):102632.
4. Huang Y#, Li S#, Jia Z, Zhao W, Zhou C, Zhang R, Ali DW, Michalak M, Chen XZ, Tang J. Transient Receptor Potential Melastatin 8 (TRPM8) Channel Regulates Proliferation and Migration of Breast Cancer Cells by Activating the AMPK-ULK1 Pathway to Enhance Basal Autophagy. Front Oncol. 2020 Dec 4;10:573127. doi: 10.3389/fonc.2020.573127.
5. Yuan W, Li S, Xi Y, Tian R, Liu Y, Chen X, Zhang R, Lyu H, Xiao S, Guo D, Zhang Q, Qin W, Yan C, Chen XZ, Zhou C, Tang J. tRNA m2G methyltransferase complex THUMPD3-TRMT112 promotes pancreatic cancer progression and autophagy via modulating TFEB translation. Mol Cancer. 2026 Jan 13;25(1):76. doi: 10.1186/s12943-025-02540-2.
6. Liu Q, Hu M, Li S, Zhang X, Zhang R, Lyu H, Xiao S, Guo D, Chen XZ, Tang J, Zhou C*.TRPM channels in human cancers: regulatory mechanism and therapeutic prospects. Biomark Res. 2024. 12(1):152.
