一、团队名称
天然药物生物制造
二、团队组成
团队固定研究人员5名，其中教授2人、副教授2人，讲师1人。
三、团队PI及团队介绍
天然药物生物制造团队由汤亚杰教授建立，目前由贾开志教授担任团队PI。贾开志，博导，教授，南京农业大学微生物学博士，中国科学院微生物研究所博士后；2013年，加入湖北工业大学发酵工程教育部重点实验室；2022年，入选湖北工业大学“南湖学者”学术带头人。主要研究工作集中在合成生物学、微生物代谢调控。主持完成国家自然科学基金2项，参加国家自然科学基金重点项目1项，在Journal of Agricultural and Food Chemistry、ACS Synthetic Biology、Applied and Environmental Microbiology、Microbial Biotechnology等合成生物学和微生物学领域经典期刊发表论文26篇，转化专利2项。
团队研究工作集中在合成生物学及微生物代谢调控。团队主要围绕治疗癌症和抗衰老药物的挖掘和生物制造，解决糖基转移酶的通用性问题，开发治疗甲硫氨酸依赖癌症的酶制剂。团队承担了国家自然科学基金项目4项，近五年发表SCI文章20篇。
四、科研成果
（1）代表性的科研项目：
国家自然科学基金项目“黑孢块菌发酵过程中VOSCs合成酶基因转录表达的调控机制”、“丙酮丁醇梭菌丁醇毒性的分子机理研究”、“大肠杆菌全局转录因子Cra对琥珀酸生物合成过程中CO2固定基因的调控机制”、“含氮杂环鬼臼类候选药物人工合成途径的体内组装”，专利许可转让项目“一种甲硫氨酸裂解酶及其编码基因和应用”。
（2）代表性论文：
1. Zhi Geng, Ting Zhao, Ke Li, Li-Ling Liang, Ming-Xuan Chen, Zhijing Zhou, Jun Dai, Zongjie Dai,Kai-Zhi Jia*. Mining and engineering the di-O-Glycosylation pattern of UGT72B1 for the highly efficient O-glycosylation of endogenous quercetin.Journal of Agricultural and Food Chemistry 2024, 72: 25219-25228. (IF=6.1)
2. Ying Huang, Kai-Zhi Jia, Wei Zhao,Li-Wen Zhu*. Insights into the regulatory mechanisms and application prospects of the transcription factor Cra[J]. Applied and Environmental Microbiology, 2024, 90(11): e01228-24.
3. Ping Li, Yin Zhou, Yingying Wu, Xiao Jiang, Xuan Wang, Xinyun Shi,Weiping Wang*. The effects of environmental factors on the synthesis of water‐solubleMonascusred pigments via submerged fermentation: a review.Journal of the Science of Food and Agriculture, 2024.
4. Yangming Hu, Yan Liu, Jiulin Zhang, Zhijing Zhou, Jiaxue Wang, Hongyang Chen, Meina Huang, Han Hu, Zongjie Dai,Kaizhi Jia*. Depletion of L-methionine in foods with an engineered thermophilic methionineγ-lyase efficiently inhibits tumor growth.Journal of Agricultural and Food Chemistry 2023, 71: 17141-17152. (IF=6.1)
5.Yin Zhou, Weiya Liu, Wendan Cao, Yong Cheng, Zhong Liu, Xiaoqiang Chen*. Effect of hydrophobic property on antibacterial activities of green tea polysaccharide conjugates againstEscherichia coli,International Journal of Biological Macromolecules, 2023, 253: 126583.
6. Fei-Fan Tan, Rui Zhu, Bin Xiong, Gui-Min Zhang, Wei Zhao,Kai-Zhi Jia*. Engineering the entrance of a flavonoid glycosyltransferase promotes the glycosylation of etoposide aglycone.ACS Synthetic Biology 2022, 11:1874-1880. (IF=5.110)
7.Yin Zhou, Xinxin Chen, Tingting Chen, Xiaoqiang Chen*. A review of the antibacterial activity and mechanisms of plant polysaccharides,Trends in Food Science & Technology 2022, 123, 264–280.
8. Quan-Lu Zhao1, Zhu-Lin Wang1, Lan Yang, Sai Zhang,Kai-Zhi Jia*. YALI0C22088g fromYarrowia lipolytica catalyzes the conversion of L-Methionine into volatile organic sulfur-containing compounds.Microbial Biotechnology 2021, 14:1462-1471.
9.Kai-Zhi Jia, Li-Wen Zhu, Xudong Qu, Shengying Li, Yuemao Shen,Qingsheng Qi, Youming Zhang, Yue-Zhong Li, and Ya-Jie Tang*. Enzymatic O-glycosylation of etoposide aglycone by exploration of the substrate promiscuity for glycosyltransferases.ACS Synthetic Biology2019, 8: 2718-2725. (IF=5.110,一区)
10. Yang-Hua Xu1,Kai-Zhi Jia1, Ya-Jie Tang*. Regulatory networks governing methionine catabolism into volatile organic sulfur-containing compounds in Clonostachys rosea.Applied and Environmental Microbiology 2018, 84:e01840-18.
11.Li-Wen Zhu, Ya-Jie Tang*. Current advances of succinate biosynthesis in metabolically engineeredEscherichia coli.Biotechnology Advances2017, 35:1040-1048 (IF=14.227)
五、研究生毕业去向
推荐到华东理工大学、北京化工大学等单位攻读博士学位，或推荐到药明康德等大型上市公司。
六、联系方式
联系人：贾开志
邮箱：kaizhijia@hbut.edu.cn，kaizhijia1@163.com
