E-mail:zx_zhao@hbut.edu.cn
研究内容：
（1） 通过生物信息学、生物计算和人工智能技术挖掘、改造具有工业应用潜力的高性能酶分子
（2） 通过构建高性能生物工具（微生物菌株、酶），实现生物可再生资源的生物法高效、高值化利用
教育/工作经历：
2010.9–2014.6中南林业科技大学学士
2014.9–2020.7华南理工大学硕士/博士
2020.8–至今湖北工业大学讲师，副教授
教学奖励：
2024年第10届中国国际大学生创新大赛全国银奖（第1指导老师）
2023-2024学年湖北工业大学本科课程教学“百优教师”
研究课题：
1. CALA脂肪酶β位置专一性的设计改造和分子机制解析（32302019），国基自然科学基金青年基金项目，2024-2026，主持
2. 脂肪酶位置选择性调控机制研究（Q20266407），湖北省教育厅科研计划青年项目，2022-2024，主持
3. 脂质分子重构制备内酯类风味化合物的酶学基础研究（31930084），国基自然科学基金重点项目，2020-2024，参与
4. 小龙虾壳生物法加工关键技术研发（2022BBA053），省科技厅科重点研发计划，2022-2024，参与
5. 多酶级联转化家禽羽毛生成高附加值非蛋白氨基酸的研究，湖北工业大学科研启动基金项目，2021-2023，主持
6. 细菌脂肪酶I.7家族位置选择性调控机制研究，发酵工程教育部重点实验室开放基金青年项目，2021-2023，主持
7. MAS1脂肪酶催化酯化反应位置选择性分子调控机制，工业微生物湖北省重点实验室开放基金项目，2022-2024，主持
8. 细胞调控与分子药物“111”引智基地青年学者国际合作项目，2024-2026，主持
研究成果：
1. Zexin Zhao, Meiling Han, Ling Zhou, Changgao Wang, Jianguo Lin, Xin Du, Jun Cai*. Biodiesel production from waste cooking oil using recombinantEscherichia colicells immobilized into Fe3O4-chitosan magnetic microspheres,Molecules, 2024, 29(15):3469.
2. Zexin Zhao, Yuan Xu, Pengpeng Zou, Long Xu, Jun Cai*. Developing a pachyman/polyvinyl alcohol-polylactic acid bilayer film as multifunctional packaging and its application in cherry tomato preservation,LWT-Food Science and Technology, 2023, 186: 115249.
3. Zexin Zhao, Jiahao Huang, Long Xu, Changgao Wang, Jun Cai*. One-step production of biodiesel by wetEscherichia colicells expressing a non-specific and methanol-resistant lipase,Process Biochemistry, 2023, 125: 75-83.
4. Zexin Zhao, Siyue Chen, Long Xu, Jun Cai, Jia Wang*, Yonghua Wang*. Structural basis for the regiospecificity of a lipase from Streptomyces sp. W007.International Journal of Molecular Sciences.2022, 23(10), 5822.
5. Zexin Zhao, Dongming Lan, Xiyu Tan, Frank Hollmann, Uwe T. Bornscheuer, Bo Yang, Yonghua Wang*, How to break the janus effect of H2O2in biocatalysis? Understanding inactivation mechanisms to generate more robust enzymes.ACS Catalysis, 2019, 9 (4): 2916-2921.
6. Zexin Zhao#, Shulin Hou#, Dongming Lan, Xiumei Wang, Jingsong Liu, Faez. Iqbal Khan, Yonghua Wang*, Crystal structure of a lipase from Streptomyces sp. Strain w007 - implications for thermostability and regiospecificity.FEBS Journal, 2017, 284 (20): 3506-3519.
7. Xuan Liu, Weifei Wang, Zexin Zhao, Long Xu, Bo Yang, Dongming Lan*, Yonghua Wang*. Monoacylglycerol lipase from marineGeobacillussp. showinglysophospholipase activity and its application in efficient soybeanoil degumming, Food Chemistry, 2023, 406 :134506.
8. Yunjian Ma, Hongjing Liang, Zexin Zhao, Bin Wu, Dongming Lan*, Frank Hollmann*, Yonghua Wang*, A Novel Unspecific Peroxygenase from Galatian marginata for Biocatalytic Oxyfunctionalization Reactions, Molecular Catalysis 2022, 531: 112707.
9. Xiumei Wang, Xiaoli Qin, Xiuting Li, Zexin Zhao, Bo Yang, and Yonghua Wang*, An efficient synthesis of lysophosphatidylcholine enriched with n-3 polyunsaturated fatty acids by immobilized MAS1 lipase. Journal of Agricultural and Food Chemistry, 2020, 68(1): 242-249.
10. Long Xu, Zexin Zhao, Yun-an Huang and Qiujin Zhu*, Preparation of Chitosan Molecularly Imprinted Polymers and the Recognition Mechanism for Adsorption of Alpha-Lipoic Acid. Molecules, 2020, 25(2), 312.
11. Weiqian Huang, Dongming Lan, Grzegorz M. Popowicz, Krzysztof M. Zak, Zexin Zhao, Hong Yuan, Bo Yang, Yonghua Wang*, Structure and characterization of Aspergillus Fumigatus lipase b with a unique, oversized regulatory subdomain. FEBS Journal, 2019, 286 (12), 2366-2380.
12. Wei Tang, Dongming Lan, Zexin Zhao, Shuang Li, Xiuting Li, Yonghua Wang*, A thermostable monoacylglycerol lipase from marine Geobacillus sp. 12amor1: Biochemical characterization and mutagenesis study. International Journal of Molecular Sciences, 2019, 20 (3), 780.
13. Xiumei Wang, Xiaoli Qin, Xiuting Li, Zexin Zhao, Bo Yang, Yonghua Wang*, Insight into the modification of phosphatidylcholine with n-3 polyunsaturated fatty acids-rich ethyl esters by immobilized mas1 lipase. Molecules, 2019, 24 (19), 3528.
14. Yanhua Liu, Dongjuan Yuan,Zexin Zhao, Dongming Lan, Bo Yang, Yonghua Wang*, A novel strategy to improve the thermostability ofPenicillium Camembertiimono- and di-acylglycerol lipase. Biochemical and Biophysical Research Communications,2018, 500 (3), 639-644.
15. 赵泽鑫,周灵,韩美玲,许源,蔡俊.结构脂质的酶法合成及应用酶工程提高其合成效果的研究进展,轻工学报. 2024,39(1):1-11.
